Non-metastatic castration resistant prostate cancer (nmCRPC) is defined as a disease state withlack of radiographic evidence of metastatic disease, a confirmed rising PSA level on continuous ADT and maintaining a castrate level of testosterone following definitive therapy.Prior to the publication of PROSPER, SPARTAN and ARAMIS, no trials have demon
Study of detachment in future ASDEX Upgrade alternative divertor configurations by means of EMC3-EIRENE
ASDEX Upgrade is preparing a hardware modification of its upper divertor in order to study alternative divertor configurations, like the X-divertor (XD) and the snowflake General divertor (SF), that are discussed as a possible solution for the power exhaust problem.Experiments characterizing the current upper divertor in single-null (SN) configurat
A Physiologically Based Pharmacokinetic Framework for Quantifying Antibody Distribution Gradients from Tumors to Tumor-Draining Lymph Nodes
Immune checkpoint blockades prescribed in the neoadjuvant setting are now under active investigation for many types of tumors, and many have shown early success.The primary tumor (PT) Face Scrubber and tumor-draining lymph node (TDLN) immune factors, along with adequate therapeutic antibody distributions to the PT and TDLN, are critical for optimal
Study on Formability Improvement of Zr-4 Sheets Based on Texture Optimization
A positioning grid is a key clamping structure for fixing the transverse and axial positions of fuel assemblies in nuclear reactors, and it is generally prepared by the transverse stamping of a Zr-4 sheet.However, the texture formed in the processing process of Zr-4 sheets can affect formability, resulting in cracking in the stamping process.Theref